![wildstar 2 step verifiction not working wildstar 2 step verifiction not working](https://massivelyop.com/wp-content/uploads/2020/12/camelot-unchained-verdant-forest-696x219.jpg)
Finally, specific deletion of Neurod2 in forebrain excitatory neurons recapitulated cellular and behavioral phenotypes found in constitutive KO mice, revealing the region-specific contribution of dysfunctional Neurod2 in symptoms. Mice heterozygous for Neurod2 had similar defects, indicating that Neurod2 is haploinsufficient. At the behavior level, Neurod2 KO mice displayed social interaction deficits, stereotypies, hyperactivity, and occasionally spontaneous seizures. Bulk RNA sequencing showed dysregulated expression of many genes associated with neuronal excitability and synaptic function, whose human orthologs were strongly associated with autism spectrum disorders (ASD). Patch-clamp recordings in layer 5 neurons of juvenile mice revealed increased intrinsic excitability. In juvenile and adults, spine density and turnover were dysregulated in apical but not basal compartments in layer 5 neurons. In Neurod2 KO embryos, cortical projection neurons over-migrated, thereby altering the final size and position of layers. Using a multi-scale approach, we set out to understand how Neurod2 deletion affects the development of the cerebral cortex in mice. While the transcription factor NEUROD2 has recently been associated with epilepsy, its precise role during nervous system development remains unclear. Molecular Psychiatry volume 26, pages 6125–6148 ( 2021) Cite this article
![wildstar 2 step verifiction not working wildstar 2 step verifiction not working](https://gamertweak.com/wp-content/uploads/2021/09/cod-2fa-not-working-1.jpg)
![wildstar 2 step verifiction not working wildstar 2 step verifiction not working](https://cdn.mos.cms.futurecdn.net/cbdb72577ef1631508834390acf0e7ba.jpg)
Disruption of NEUROD2 causes a neurodevelopmental syndrome with autistic features via cell-autonomous defects in forebrain glutamatergic neurons